Featured articles:  (click for PDF)

Forthcoming Papers:  (underline = Pool lab member; * = equal contributions)

da Silva Ribeiro T, GalvŠn JA, Pool JE (2022) SNP-level FST outperforms whole-window statistics for detecting soft sweeps in local adaptation. In Review.  LINK

All Published Papers:
  (underline = Pool lab member; * = equal contributions)

Duranton M, Pool JE (2022) Interactions between natural selection and recombination shape the genomic landscape of introgression. Mol Biol Evol, Accepted.  LINK

Lange JD, Bastide H, Lack JB, Pool JE (2022) A population genomic assessment of three decades of evolution in a natural Drosophila population. Mol Biol Evol, 39:msab368.  PDF

Sprengelmeyer QD, Lack JB, Braun DT, Monette MJ, Pool JE (2022) The evolution of larger size in high altitude Drosophila melanogaster has a polymorphic genetic architecture. G3, 12:jkab454.  PDF

Huang Y, Lack JB, Hoppel GT, Pool JE (2022) Gene regulatory evolution in cold-adapted fly populations neutralizes plasticity and may undermine genetic canalization. Genome Biol Evol, 14:evac050.

Huang Y, Lack JB, Hoppel GT, Pool JE (2021) Parallel and Population-specific Gene Regulatory Evolution in Cold-Adapted Fly Populations. Genetics, 218:iyab077.  PDF 

Sprengelmeyer QD, Pool JE (2021) Ethanol resistance in Drosophila melanogaster has increased in parallel cold-adapted populations and shows a variable genetic architecture within and between populations. Ecol Evol, 11:15364–15376.  PDF

Machado HE*, Bergland AO*, Taylor R, Tilk S, Behrman E, Dyer K, Fabian DK, Flatt T, GonzŠlez J, Karasov TL, Kim B, Kozeretska I, Lazzaro BP, Merritt TJS, Pool JE, O’Brien K, Rajpurohit S, Roy PR, Schaeffer SW, Serga S, Schmidt P, Petrov DA (2021) Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila. eLife, 10:e67577.

Sprengelmeyer QS
, Mansourian S, Lange JD, Matute DR, Cooper BS, Jirle EV, Stensmyr MC, Pool JE (2020) Recurrent collection of Drosophila melanogaster from wild African environments and genomic insights into species history. Mol Biol Evol, 37:627-638.  PDF

Mansourian S, Engin A, Jirle EV, Ramesh V, Rehermann G, Becher PG, Pool JE, Stensmyr MC (2018) Wild African Drosophila melanogaster are seasonal specialists on marula fruit. Curr Biol, 28:3960-3968. 

Lange JD, Pool JE (2018) Impacts of recurrent hitchhiking on divergence and demographic inference in Drosophila. Genome Biol Evol,

Groth BR
*, Huang Y*, Monette MJ, Pool JE (2018) Directional selection reduces developmental canalization against genetic and environmental perturbations in Drosophila wings. Evolution,

Pool JE
, Braun DT, Lack JB (2017) Parallel evolution of cold tolerance within Drosophila melanogaster.
Mol Biol Evol, 34:349-360.  PDF

Hervas S, Sanz E, Casillas S, Pool JE, Barbadilla A (2017) PopFly: the Drosophila population genomics browser. Bioinformatics, 33:2779–2780.  PDF

Bastide H, Lange JD, Lack JB, Yassin A, Pool JE (2016) A variable genetic architecture of melanic evolution in Drosophila melanogaster. Genetics, 204:1295-1306.  PDF

Pool JE (2016) Genetic mapping by bulk segregant analysis in Drosophila: experimental design and simulation-based inference. Genetics, 204:1295-1306PDF

Lack JB, Lange JD, Tang AD, Corbett-Detig RB, Pool JE (2016) A thousand fly genomes: an expanded Drosophila Genome Nexus. Mol Biol Evol, 33:3308-3313.  PDF

Lack JB, Monette MJ, Johanning EJ, Sprengelmeyer QD, Pool JE (2016) Decanalization of wing development accompanied the evolution of large wings in high altitude Drosophila. Proc Natl Acad Sci USA 113:1014-1019.  PDF

Lack JB
, Yassin A, Johanning EJ, Sprengelmeyer QD, David JR, Pool JE (2016)
Life history evolution and cellular mechanisms associated with increased size in high altitude Drosophila. Evol Ecol 6:5893-5906.  PDF

Yassin A, Debat V, Bastide H, Gadesweski N, David JR*, Pool JE* (2016) Recurrent specialization on a toxic fruit in an island Drosophila population. Proc Natl Acad Sci USA 113:4771-4776.  PDF

Yassin A, Bastide H, Chung H, Veuille M, David JR, Pool JE (2016) Ancient balancing selection at tan underlies female color dimorphism in Drosophila erecta. Nat Commun 7:10400.  PDF

Yassin A*, Delaney EK*, Reddieux A, Bastide H, Appleton N, Seher T, Podlaja O, Lack JB, Barmina O, Allen S, David JR, Chenoweth S, Pool JE, Kopp A (2016) Pdm3 is responsible for recurrent evolution of female-limited color dimorphism in Drosophila. Curr Biol, 26:2412-2422.  PDF

Lange JD, Pool JE (2016) A haplotype method detects diverse scenarios of local adaptation from genomic sequence variation. Mol Ecol 25:3081-3100.  PDF

Gasch AP, Payseur BA, Pool JE (2016) The power of natural variation for model organism biology. Trends Genet 32:147-154.  PDF

Pool JE (2015) The mosaic ancestry of the Drosophila Genetic Reference Panel and the
D. melanogaster reference genome reveals a network of epistatic fitness interactions. Mol Biol Evol 32:3236-3251.  PDF

Lack JB, Cardeno CM, Crepeau MW, Taylor W, Corbett-Detig RB, Stevens KA, Langley CH, Pool JE (2015) The Drosophila Genome Nexus: a population genomic resource of 623 Drosophila melanogaster genomes, including 197 from a single ancestral range population.  Genetics, 199:1229-1241.  PDF

Fabian DK, Lack JB, Vinayak M, SchlŲtterer C, Schmidt PS, Pool JE, Flatt T (2015) Spatially varying selection shapes life history clines among populations of Drosophila melanogaster from sub-Saharan Africa. J Evol Biol 28:826-840.

Bastide H*, Yassin A*, Johanning EJ, Pool JE (2014) Pigmentation in Drosophila melanogaster reaches its maximum in Ethiopia and correlates most strongly with ultra-violet radiation in sub-Saharan Africa. BMC Evol Biol 14:179.

Pitchers W, Pool JE, Dworkin I (2013) Altitudinal clinal variation in wing size and shape in African Drosophila melanogaster: one cline or many? Evolution 67:438-452.

Hua Z, Pool JE, Schmitz RJ, Schultz MD, Shiu S-H, Ecker JR, Vierstra RD (2013) Epigenomic programming contributes to the genomic drift evolution of the F-Box protein superfamily in Arabidopsis. Proc Natl Acad Sci USA 110:16927-16932.

Pool JE
, Corbett-Detig RB, Sugino RP, Stevens KA, Cardeno CM, Crepeau MW, Duchen P,  Emerson JJ, Saelao P, Begun, DJ, Langley CH (2012) Population genomics of sub-Saharan Drosophila melanogaster: African diversity and non-African admixture. PLoS Genetics 8:e1003080.
  PDF  Supplement

Pool Publications:

Langley CH, Stevens KA, Cardeno C, Lee Y-C, Schrider D, Pool JE, Langley S, Suarez C, Corbett-Detig R, Kolaczkowski B, Kern AD, Dewey CN, Song Y, Hahn MW, Begun DJ (2012) Population genomics of Drosophila melanogaster. Genetics 192:533-598.  PDF

Wang L, Luzynski K, Pool JE, Janoušek V, Dufkova P, MrkvicovŠ VyskočilovŠ M, Teeter K, Nachman M, Munclinger P, Macholan M, Pialek J, Tucker PK (2011) Measures of linkage disequilibrium among neighboring SNPs indicate asymmetries across the house mouse hybrid zone. Mol Ecol 14:2985-3000.

Yi X*, Liang Y*, Huerta-Sanchez E*, Jin X*, Cuo ZXP*, Pool JE*, et al. (2010) Sequencing of fifty human exomes reveals adaptation to high altitude. Science 329:75-78.
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Pool JE, Hellmann I, Jensen JD, Nielsen R (2010) Population genetic inference from genomic sequence variation. Genome Res 20:291-300.

Rebeiz M, Pool JE, Kaessner V, Aquadro CF, Carroll SB (2009) Stepwise modification of a modular enhancer underlies local adaptation in a Drosophila population. Science 326:1663-1667.
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Pool JE, Nielsen R (2009) Inference of historical changes in migration rate from the lengths of migrant tracts. Genetics 181:711-719.

Wang J, et al. (2008) The diploid genome sequence of an Asian individual. Nature 456:60-65.

Pool JE, Nielsen R (2008) The impact of founder events on chromosomal variability in multiply mating species. Mol Biol Evol 25:1728-1736.

Pool JE, Nielsen R (2007) Population size changes reshape genomic patterns of diversity. Evolution 62:3001-3006.
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Pool JE, Aquadro CF (2007) The genetic basis of adaptive pigmentation variation in Drosophila melanogaster. Mol Ecol 16:2844-2851. 

Wong A, Jensen JD, Pool JE, Aquadro CF (2007) Phylogenetic incongruence in the Drosophila melanogaster species group. Mol Phyl Evol 43:1138-1150.

Pool JE, Aquadro CF (2006) History and structure of sub-Saharan populations of Drosophila melanogaster. Genetics 174:915-929.

Pool JE, Wong A, Aquadro CF (2006) Finding of male-killing Spiroplasma infecting Drosophila melanogaster in Africa implies transatlantic migration of this endosymbiont. Heredity 97:27-32.

Pool JE, Bauer DuMont V, Mueller JL, Aquadro CF (2006) A scan of molecular variation leads to the narrow localization of a selective sweep affecting both Afrotropical and cosmopolitan populations of Drosophila melanogaster. Genetics 172:1093-1105.